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實驗室的長遠目標(biāo)是探索真核細胞維持染色體穩(wěn)定性的機制和細胞衰老的機理。我們用酵母為模型，聚焦以下研究方向：

（1）構(gòu)建“最小基因組”真核細胞；

（2）染色體末端的端粒復(fù)制、結(jié)構(gòu)調(diào)控、進化；

（3）基因組（染色體）穩(wěn)定性與細胞衰老機制。

( ^#共同第一作者, *通訊作者)

1.構(gòu)建“最小基因組”真核細胞：

1. Xueting Zhu, Shaochun Liu, Tiantian Ye, Xin Gu, Feiyu Pu, Zhen Zhou, Zhi?Jing Wu and Jin?Qiu Zhou*. (2025) Artificial chromosome reorganization reveals high plasticity of the budding and fission yeast genomes. Genome Biology 26:229. https://doi.org/10.1186/s13059-025-03689-1.
2. Yuang Wang Y, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou* and Yun Zhao*. (2023) Chromosome territory reorganization through artificial chromosome fusion is compatible with cell fate determination and mouse development. Cell Discovery 9:11.
3. Xin Gu, Tiantian Ye, Xiao-Ran Zhang, Lingyun Nie, Huan Wang, Wei Li, Rui Lu, Chuanhai Fu, Li-Lin Du*and Jin-Qiu Zhou*. (2022) Single-chromosome fission yeast models reveal the configuration robustness of a functional genome. Cell Reports 40, 111237.
4. Zhi-Jing Wu, Jia-Cheng Liu, Xin Man, Xin Gu, Ting-Yi Li, Chen Cai, Ming-Hong He, Yangyang Shao, Ning Lu, Xiaoli Xue, Zhongjun Qin, Jin-Qiu Zhou*. (2020) Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions. eLife 2020;9:e53144 DOI: 10.7554/eLife.53144.
5. Yangyang Shao, Ning Lu, Chen Cai, Fan Zhou, Shanshan Wang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin*. (2019) A single circular chromosome yeast. Cell Research 29: 87-89.
6. Yangyang Shao, Ning Lu, Zhenfang Wu, Chen Cai, Shanshan Wang, Ling-Li Zhang, Fan Zhou, Shijun Xiao, Lin Liu, Xiaofen Zeng, Huajun Zheng, Chen Yang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin* (2018) Creating a functional single-chromosome yeast. Nature 560, 331-335.

2.染色體末端的端粒復(fù)制、結(jié)構(gòu)調(diào)控、進化：

1. Tiantian Ye, Qingqing Yuan, Shuheng Wu, Jing-Tong Zhao, Zhi-Jing Wu, Jia-Cheng Liu, Wei Wu and Jin-Qiu Zhou*. (2025) Asymmetrical end structures of leading and lagging telomeres in Saccharomyces cerevisiae dictate the nature of the end replication problem. Cell Reports 44, 116622.
2. Can?Hu,?Xue-Ting?Zhu,?Ming-Hong?He,?Yangyang?Shao,?Zhongjun?Qin,?Zhi-Jing?Wu*, Jin-Qiu?Zhou*. (2024) Elimination of subtelomeric repeat sequences exerts little effect on telomere functions in?Saccharomyces cerevisiae. eLife 12:RP91223. https://doi.org/10.7554/eLife.91223.4.
3. Yue Pan, Can Hu, Lin-Jun Hou, Yu-Long Chen, Jiantao Shi, Jia-Cheng Liu*, Jin-Qiu Zhou*. (2023) Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. DNA Repair 127, 103512.
4. Qian-Xi Li, Jia-Cheng Liu, Ming-Hong He and Jin-Qiu Zhou*. (2022) Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity. Biochemical Journal 479(23): 2433–2447.
5. Jia-Cheng Liu, Qian-Jin Li, Ming-Hong He, Can Hu, Pengfei Dai, Fei-Long Meng, Bo O. Zhou and Jin-Qiu Zhou*. (2020) Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes. Nucleic Acids Research ?48(22): 12792–12803.
6. Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou*. (2018) Yeast KEOPS complex regulates telomere length independently of its t⁶A modification function. Journal of Genetics and Genomics 45(5): 247-257.
7. Zhenfang Wu*, Ming-Hong He, Ling-li Zhang, Jun Liu, Qiong-Di Zhang, Jin-Qiu Zhou*. (2018) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA Repair 72, 64-76.
8. Zhenfang Wu, Jun Liu, Qiong-Di Zhang, De-Kang Lv, Nian-Feng Wu and Jin-Qiu Zhou*. (2017) Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Research 45(6): 3308-3322.
9. Yi-Min Duan, Bo-O Zhou, Jing Peng, Xia-Jing Tong, Qiong-Di Zhang and Jin-Qiu Zhou*. (2016) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast. Journal of Genetics and Genomics 43(7): 451-465.
10. Xiao-Hong Fu^#, Yi-Min Duan^#, Yu-Ting Liu, Chen Cai, Fei-Long Meng, Jin-Qiu Zhou*. (2014) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors. PLoS One 9(3): e90644.
11. Yan Hu^#, Hong-Bo Tang^#, Ning-Ning Liu^#, Xia-Jing Tong, Wei Dang, Yi-Min Duan, Xiao-Hong Fu, Yang Zhang, Jing Peng, Fei-Long Meng, Jin-Qiu Zhou*. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genetics 9(1): e1003208.
12. Qian-Jin Li, Xia-Jing Tong, Yi-Min Duan, Jin-Qiu Zhou*. (2013) Characterization of the intramolecular G-quadruplex promoting activity of Est1. FEBS Letter 587(6): 659-665.
13. Jing Peng and Jin-Qiu Zhou*. (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Research 40(2): 581-593.
14. Xia-Jing Tong, Qian-Jin Li, Yi-Min Duan, Ning-Ning Liu, Ming-Liang Zhang, and Jin-Qiu Zhou*. (2011) Est1 protects telomeres and inhibits subtelomeric Y′-element recombination. Molecular and Cellular Biology 31(6): 1263-1274.
15. Bo O. Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A. Lenzmeier, Jin-Qiu Zhou*. (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLoS Genetics 7(1): e1001272.
16. Ning-Ning Liu, Tian Xu Han, Li-Lin Du and Jin-Qiu Zhou (2010) A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. Cell Research 20:963-965.
17. Fei-Long Meng, Xiao-Fen Chen, Yan Hu, Hong-Bo Tang, Wei Dang, Jin-Qiu Zhou (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Research 20:495-498.
18. Ming-Liang Zhang, Xia-Jing Tong, Xiao-Hong Fu, Bo O. Zhou, Jianyong Wang, Xin-Hua Liao, Qian-Jin Li, Ning Shen, Jianping Ding, Jin-Qiu Zhou*. (2010) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nature Structural & Molecular Biology 17(2): 202-209.
19. Wei Qian*, Xiao-Hong Fu, Jin-Qiu Zhou. (2010) Purification and characterization of Stn1p, a single-stranded telomeric DNA binding protein. Protein Expression and Purification 73: 107–112.
20. Fei-Long Meng, Yan Hu, Ning Shen, Xia-Jing Tong, Jianyong Wang, Jianping Ding and Jin-Qiu Zhou* (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. THE EMBO JOURNAL 28: 1466-1478.
21. Wei Qian, Jianyong Wang, Na-Na Jin, Xiao-Hong Fu, Yi-Chien Lin, Jing-Jer Lin, Jin-Qiu Zhou* (2009) Ten1p promotes the telomeric DNA binding acivity of Cdc13p: an implication for its function in telomere length regulation. Cell Research 19: 850-863.
22. Cui-Ping Yang, Yong-Bin Chen, Fei-Long Meng and Jin-Qiu Zhou* (2006) Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Research 34:407-416.
23. Deng-Hong Zhang, Bo Zhou, Yu Huang, Lu-Xia Xu and Jin-Qiu Zhou* (2006) The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Research 34:1393-1404.
24. Yong-Bin Chen, Cui-Ping Yang, Rong-Xia Li, Rong Zeng, and Jin-Qiu Zhou* (2005) Def1p is involved in telomere maintenance in budding yeast. The Journal of Biological Chemistry 280:24784-24791.
25. Xin-Hua Liao, Ming-Liang Zhang, Cui-Ping Yang, Lu-Xia Xu and Jin-Qiu Zhou* (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochemical Journal 390:169-176.
26. Jin-Qiu Zhou ^#, Haiyan Qi ^#, Vincent P. Schulz, Maria K. Mateyak, Ellen K. Monson, and Virginia A. Zakian* (2002) Schizosaccharomyces pombe pfh1(+) Encodes an Essential 5' to 3' DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases. Molecular Biology Of The Cell 13:2180-2191.
27. Andreas S. Ivessa ^#, Jin-Qiu Zhou ^#, Schulz VP, Monson EK and Zakian VA* (2002) Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes & Development 16:1383-1396.
28. Jin-Qiu Zhou, Ellen K Monson⁺, Shu-Chun Teng⁺, Vince P Schulz⁺, Virginia A. Zakian* (2000) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 289: 771-774.
29. Andreas S. Ivessa^#, Jin-Qiu Zhou ^# and Virginia A. Zakian* (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100: 479-489.

3.基因組（染色體）穩(wěn)定性與細胞衰老機制：

1. Ting Gong^#, Xin Gu^#, Yu-Ting Liu, Zhen Zhou, Ling-Li Zhang, Yang Wen, Wei-Li Zhong, Guo-Liang Xu, Jin-Qiu Zhou*. (2020) Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation. Journal of Genetics and Genomics 47(2): 105-114.
2. Ming-Hong He^#, Jia-Cheng Liu^#, Yi-Si Lu, Zhi-Jing Wu, Ying-Ying Liu, Zhenfang Wu, Jing Peng, Jin-Qiu Zhou*. (2019) KEOPS complex promotes homologous recombination via DNA resection. Nucleic Acids Research 47(11): 5684-5697.
3. Ling-Li Zhang, Zhenfang Wu, Jin-Qiu Zhou*. (2018) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. Journal of Genetics and Genomics 45(9): 467-476.
4. Zhen Zhou^#, Yu-Ting Liu^#, Li Ma, Ting Gong, Ya-nan Hu, Hong-Tao Li, Chen Cai Ling-Li Zhang, Gang Wei and Jin-Qiu Zhou*. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife 6: e30178 DOI: 10.7554/eLife.30178
5. Xiaoguang Liu, Wei Wei, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li* and Jiemin Wong*. (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 3, 17016.
6. Jun Liu*, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu , Ting Gong, Hong-Tao Li, Jin-Qiu Zhou*. (2016) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast. Aging 8(11): 2827-2847.
7. Fengjuan Lv, Tianlong Zhang, Zhen Zhou, Shuaixin Gao, Catherine CL Wong, Jin-Qiu Zhou, Jianping Ding*. (2015) Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell Discovery 1, 15037.
8. Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen*, Jin-Qiu Zhou*. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochemical Journal 467(3): 507-515.
9. Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou*. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PLoS Genetics 11(3): e1005071.
10. Bo O. Zhou and Jin-Qiu Zhou*. (2011) Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation. The Journal of Biological Chemistry 286(40): 34770-34776.
11. Shan-Shan Wang, Bo O. Zhou*, and Jin-Qiu Zhou*. (2011) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 promoter. Molecular and Cellular Biology 31(15): 3171-3181.
12. Yiwei Liu^#, Hongda Huang^#, Bo O Zhou, Shan-Shan Wang, Yingxia Hu, Xu Li, Jianping Liu, Jianye Zang, Liwen Niu, Jihui Wu, Jin-Qiu Zhou, Maikun Teng, Yunyu Shi. (2010) Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing. Journal of Biological Chemistry 285:4251-62.
13. Bo O. Zhou, Shan-Shan Wang, Lu-Xia Xu, Fei-Long Meng, Yao-Ji Xuan, Yi-Min Duan, Jian-Yong Wang, Hao Hu, Xianchi Dong, Jianping Ding, and Jin-Qiu Zhou*. (2010) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation. Molecular and Cellular Biology 30(10): 2391-2400.
14. Jia-Lei Hu, Bo O. Zhou, Run-Rui Zhang, Kang-Ling Zhang, Jin-Qiu Zhou*, Guo-Liang Xu*. (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. PNAS 106: 187-192.
15. Xiao-Fen Chen, Fei-Long Meng, Jin-Qiu Zhou* (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genetics 5: e1000535.
16. Jing Zhou, Bo O. Zhou, Brian A. Lenzmeier and Jin-Qiu Zhou* (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Research 37: 3699-3713.
17. Xiao-Hong Fu, Fei-Long Meng, Yan Hu and Jin-Qiu Zhou* (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7:746-757.
18. Jin-Qiu Zhou, Hua He, Cheng-Keat Tan, Kathleen M. Downey, Antero G. So* (1997) The small subunit is required for functional interaction of DNA polymerase delta with the proliferating cell nuclear antigen. Nucleic Acids Research 27:1094-1099.
19. Jin-Qiu Zhou, Cheng-Keat Tan, Antero G. So, Kathleen M. Downey* (1996) Purification and characterization of the human catalytic subunit of human DNA polymerase delta expressed in baculovirus-infected insect cells. Journal of Biological Chemistry 271:29740-29745.

科普：

翻譯：《抗衰老革命》，周金秋等譯，“上?？茖W(xué)技術(shù)出版社”發(fā)行（ISBN 978-7-5478-588-3），原著《The Telomerase Revolution》（原著作者：Michael Fossel，出版商：BenBella Books Inc.）。

文章：細胞端粒藏著長壽的秘密（《人民日報》“科技大觀”版），劉軍，周金秋，《人民日報》，2015年5月4日，22 版

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