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宋昕陽(yáng)
研究員，研究組長(zhǎng)，博士生導(dǎo)師
E-mail: xinyang.song@sibcb.ac.cn
實(shí)驗(yàn)室主頁(yè):

個(gè)人簡(jiǎn)介：

　　2007年畢業(yè)于中國(guó)藥科大學(xué)生命科學(xué)與技術(shù)學(xué)院，獲理學(xué)學(xué)士學(xué)位。2014年畢業(yè)于中科院上海生命科學(xué)研究院健康科學(xué)研究所(現(xiàn)上海營(yíng)養(yǎng)與健康研究所)，獲理學(xué)博士學(xué)位。2016至2021年于美國(guó)哈佛醫(yī)學(xué)院免疫學(xué)系從事博士后研究。2021年6月起任中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心(生物化學(xué)與細(xì)胞生物學(xué)研究所)研究員，研究組長(zhǎng)，博士生導(dǎo)師。

社會(huì)任職：

研究方向：

黏膜穩(wěn)態(tài)與疾病

研究工作：

　　機(jī)體的黏膜表面存在大量與宿主免疫系統(tǒng)相互作用的共生微生物。這些微生物包括細(xì)菌，真菌，病毒以及少量原生生物，其基因組合集被稱為微生物組。作為人體的“第二基因組”，其所編碼的代謝通路可將來(lái)源于機(jī)體和食物的天然產(chǎn)物轉(zhuǎn)化為包括萜類，脂類，寡糖，氨基酸以及脂肪酸衍生物在內(nèi)的多種小分子代謝產(chǎn)物。此外，人體微生物組的代謝通路亦可對(duì)異生化合物如藥物分子進(jìn)行多種修飾。近年來(lái)，雖然高通量測(cè)序技術(shù)的發(fā)展使得鑒定或預(yù)測(cè)大量微生物來(lái)源的小分子及其生物合成相關(guān)基因成為可能，但我們?nèi)圆磺宄@些小分子代謝產(chǎn)物所介導(dǎo)的信號(hào)網(wǎng)絡(luò)調(diào)控宿主黏膜免疫系統(tǒng)發(fā)育與功能，進(jìn)而影響機(jī)體生理與病理的內(nèi)在機(jī)理。由此，本實(shí)驗(yàn)室的研究重點(diǎn)在于系統(tǒng)闡明各類微生物來(lái)源的小分子代謝產(chǎn)物調(diào)控宿主黏膜免疫穩(wěn)態(tài)以及疾病易感性的分子機(jī)理。依據(jù)前期的分子機(jī)理研究，我們亦致力于開(kāi)發(fā)基于共生微生物基因組編輯技術(shù)的新型診斷與治療途徑。
　　我們將利用無(wú)菌小鼠模型和小鼠遺傳修飾或疾病模型，并結(jié)合免疫學(xué)，微生物學(xué)(特別是細(xì)菌遺傳學(xué))，分子生物學(xué)，基因組學(xué)，轉(zhuǎn)錄組學(xué)以及代謝組學(xué)等多學(xué)科技術(shù)手段開(kāi)展以下三個(gè)方向的科學(xué)研究：
　　1. 黏膜免疫細(xì)胞發(fā)育，成熟的分子機(jī)理及其功能；
　　2. 共生微生物對(duì)于黏膜免疫細(xì)胞調(diào)控的分子機(jī)理；
　　3. 新型共生微生物基因組編輯工具的開(kāi)發(fā)與應(yīng)用。

承擔(dān)科研項(xiàng)目情況：

代表論著：

1. Zhang H, Xie Y, Cao F, Song X*. 2024. Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions. Gut Microbes 16 (1), 2382336. (* Correspondence author, Invited review)
2. Li C, Zhang P, Xie Y, Wang S, Guo M, Wei X, Zhang K, Cao D, Zhou R, Wang S, Song X*, Zhu S*, Pan W*. 2024. Enterococcus-derived tyramine hijacks a2A-adrenergic receptor in intestinal stem cells to exacerbate colitis. Cell Host Microbe 32 (6), 950-963. e8. (* Co-correspondence author)
3. Cong J, Liu P, Han Z, Ying W, Li C, Yang Y, Wang S, Yang J, Cao F, Shen J, Zeng Y, Bai Y, Zhou C, Ye L, Zhou R, Guo C, Cang C, Kasper DL, Song X, Dai L, Sun L, Pan W, Zhu S. 2024. Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8⁺ T cell effector functions. Immunity 57 (4), 876–889. e11.
4. Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed JD, Ringel A, Barends J, Wu C, Balskus EP, Thiagarajah JR, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper S. 2024. Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol 18 (2):101350.
5. Xie Y, Zhang H, Song X*. 2024. AEP promotes aberrant RNA splicing through DDX3X cleavage in solid tumors. J Clin Invest 134 (3):e177609. (* Correspondence author, Invited commentary)
6. Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL. 2024. Gut complement induced by the microbiota combats pathogens and spares commensals. Cell 187 (4), 897–913. e18.
7. Peng H, Qiu J, Zhou Q, Zhang Y, Chen Q, Yin Y, Su W, Yu S, Wang Y, Cai Y, Gu M, Zhang H, Sun Q, Hu G, Wu Y, Liu J, Chen S*, Zhu Z*, Song X*, Zhou J*. 2023. Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis. Immunity?56 (12), 2773–2789. e8. (* Co-correspondence author)
8. Song X^?*, Zhang H^?, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W, Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF & Kasper DL*. 2023. Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature 619 (7971), 837-843. (? Co-first author, * Co-correspondence author)
9. Yang T, Wang G, Zhang M, Hu X, Li Q, Yun F, Xing Y, Song X, Zhang H, Hu G, Qian Y. 2023. Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis. Cell Rep 42 (11):113377.
10. Song X*, Sun X*, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. 2020. Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis. Nature?577 (7790), 410-415. (* Co-first author)
11. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh SF, Mekalanos J, Kasper DL. 2020. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature 577 (7791), 543–548.
12. Yang D, Xing Y, Song X, Qian Y. 2020. The impact of lung microbiota dysbiosis on inflammation. Immunology 159 (2), 156-166.
13. Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, Wang H, Chen J, Wu M, Song X, Qian Y. 2019. Dysregulated lung commensal bacteria drive Interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles. Immunity 50 (3), 692-706. e7.
14. Zhang Y, Xin D, Wang Z, Song X, Sun Y, Zou Q, Yue J, Zhang C, Zhang J, Liu Z, Zhang X, Zhao T, Su B, Chin Y. 2019. STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J 38 (6):e99595.
15. Chen S, Yun F, Yao Y, Cao M, Zhang Y, Wang J, Song X, Qian Y. 2018. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein. J Exp Med 215 (11), 2850-2867.
16. Cao M, Chen F, Xie N, Cao M, Chen P, Lou Q, Zhao Y, He C, Zhang S, Song X, Sun Y, Zhu W, Mou L, Luan S & Gao H. 2018. c-Jun N-terminal kinases differentially regulate TNF- and TLRs-mediated necroptosis through their kinase-dependent and-independent activities. Cell Death Dis 9 (12):1140.
17. Shao X, Chen S, Yang D, Cao M, Yao Y, Wu Z, Li N, Shen N, Li X, Song X*, Qian Y*. 2017. FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep 7 (1), 7024. (* Co-correspondence author)
18. Yao Y, Chen S, Cao M, Fan X, Yang T, Huang Y, Song X, Li Y, Ye L, Shen N, Shi Y, Li X, Wang F, Qian Y. 2017. Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nature Commun 8 (1), 15402.
19. Song X*, He X*, Li X, Qian Y. 2016. The roles and functional mechanisms of Interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 13 (4), 418-431. (Invited review, * Co-first author)
20. Song X*, Dai D*, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. 2015. Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage. Immunity?43 (3), 488–501. (* Co-first author)
21. Song X*. 2015. Intestinal microbiota mining: a Th17/Treg cell perspective. Eur J Bio Med Res 1 (4), 28-35. (Invited review, * Correspondence author)
22. Song X*, Gao H*, Lin Y, Yao Y, Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 40 (1), 140-152. (* Co-first author)
23. Song X, Gao H, Qian Y. 2014. Chapter V: Th17 differentiation and their pro-inflammation function. Springer Press. Adv Exp Med Biol 841:99-151. (Invited book chapter)
24. Song X, Qian Y. 2013. Peli1 sets the CNS on fire. Nat Med 19 (5):536-538. (Invited preview)
25. Song X, Qian Y. 2013. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal 25 (12):2335-2347. (Invited review)
26. Song X, Qian Y. 2013. The activation and regulation of IL-17 receptor-mediated signaling. Cytokine 62 (2):175-182. (Invited review)
27. Zhu S, Pan W, Song X, Liu Y, Tang Y, Wang H, Liu W, Shi Y, He D, J.B Harley, Shen N, Qian Y. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med 18 (7):1077-1086.
28. Song X, Zhu S, Shi P, Liu Y, Shi Y, Levin SD, Qian Y. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat Immunol 12 (12):1151-1158.
29. Zhu S, Pan W, Shi P, Gao H, Zhao F, Song X, Liu Y, Zhao L, Li X, Shi Y, Qian Y. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling. J Exp Med 207 (12):2647-2662.

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個(gè)人簡(jiǎn)介：

社會(huì)任職：

研究方向：

研究工作：

承擔(dān)科研項(xiàng)目情況：

代表論著：

獲獎(jiǎng)及榮譽(yù)：

研究組成員：