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　　1998年畢業(yè)于中國醫(yī)科大學七年制外文系，獲得醫(yī)學學士學位;2003年3月畢業(yè)于日本神戶大學，獲得醫(yī)學博士學位;2003年6月至2008年7月在美國哈佛醫(yī)學院細胞生物系從事博士后研究;2008年7月起任中國科學院上海生命科學研究院生物化學與細胞生物學研究所研究員，博士生導師和研究組長。

　　真核細胞中，核膜將貯存遺傳信息的DNA與翻譯遺傳信息的核糖體分隔在細胞核與細胞質(zhì)中。由RNA介導的遺傳信息跨核膜傳遞為所有真核生物生命活動所必需。新生pre-mRNA在細胞核內(nèi)完成一系列復雜加工后，成熟mRNA被轉(zhuǎn)運到細胞質(zhì)中進行翻譯。mRNA出核轉(zhuǎn)運與pre-mRNA加工過程相互偶聯(lián)，確保遺傳信息的精準表達。細胞核中普遍存在RNA質(zhì)量監(jiān)控系統(tǒng)，可快速識別并降解攜帶錯誤遺傳信息的或異常mRNA，從而保證遺傳信息的準確傳遞。新生轉(zhuǎn)錄本被快速、準確地分選到出核或降解通路是遺傳信息高效、精準傳遞的基本保證，具有重要生物學意義。本實驗室自2008年成立以來，主要圍繞“新生轉(zhuǎn)錄本出核和降解的命運決定與調(diào)控”這一基因表達領域的關鍵科學問題，系統(tǒng)性地開展mRNA出核與加工的復雜關聯(lián)、RNA的質(zhì)量控制和核內(nèi)降解及其調(diào)控兩個方向的研究工作。具體如下。

　　利用分子與細胞生物學、生物化學、化學生物學及多種組學研究手段及技術，重點研究：

　　1、mRNA出核與pre-mRNA加工的復雜關聯(lián);

　　2、RNA的質(zhì)量控制和核內(nèi)降解及其調(diào)控;

　　3、細胞核亞結(jié)構(gòu)調(diào)控RNA出核或降解的生理病理機制。

1. Zhang L#, Wang JS#, Tang ZD#, Lin Z, Su RB, Hu NJ, Tang Y, Ge GX, Fan J, Tong MH, Xue YC*, Zhou Y*, and Cheng H*. The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation. Nature Communications?(2025). DOI: 10.1038/s41467-025-57898-0
2. Fan J#*, Wang YM#, Wen MM#, Tong D#, Wu K, Yan KM, Jia PX, Zhu Y, Liu QY, Zou HC, Zhao P, Lu FL Yun CH, Xue YC, Zhou Y*, and Cheng H*. Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting. Mol Cell (2024), DOI:10.1016/j.molcel.2024.09.032
3. Wang KY#, Zhang L#, Zhang SR#, Liu Y#, Mao JW#, Liu Z#, Xu L, Li KJ, Wang JS, Ma YL, Wang JY, Li HT, Wang ZF*, Li GH*, Cheng H*, Ye ML*. Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers. Nature Communications?(2024), DOI:?10.1038/s41467-024-51979-2
4. Wang CS#, Xu L#, Du C#, Yun H#, Wang K#, Liu H, Ye ML*, Fan J*, Zhou Y*, and Cheng H*. CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing. EMBO J (2023) 114051R1
5. Fu X#, Li S#, Jia M#, Xu B, Yang L, Ma R, Cheng H, Yang W*, Hu P*. Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation. Cell Regeneration (2022)11(13), DOI: 10.1186/s13619-022-00114-x
6. Chen C#, Tan M, Wu Z, Zhang Y, He F, Lu Y, Li S, Cao M, Li G, Wu J, Cheng H*, Lei M*. Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Science Bulletin (2021) 66(23): 2347-2352
7. Wang YM#, Fan J#*, Wang JS, Zhu Y, Xu L, Tong D, Cheng H*. ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation. Nucleic Acids Research (2021) 49(18): 10630-10643
8. Wei MY#, Huang JS, Li GW, Jiang BW, Cheng H, Liu XY, Jiang XY, Zhang X, Yang L, Bao L* ,? Wang B*.Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation. Cell Reports (2021) 35, 109053
9. Cheng LC#, Zheng DH, Zhang Q, Guvenek A, Cheng H, and Tian B*. Alternative 3 UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum Cell Reports (2021) 36, 109407
10. Wang JS#, Cheng H*. Out or decay: fate determination of nuclear RNAs. Essays in Biochemistry (2020), 64(6): 895-905
11. Wang LT^#, Fan J^#, Han LL^#, Qi HN^#, Wang YM, Wang HY, Chen SL, Du L, Li S, Zhang YB, Tang W，Ge GX, Pan WJ*, Hu P*, Cheng H*. The micropeptide LEMP plays an evolutionarily conserved role in myogenesis. Cell Death Dis (2020) 11(5):357 DOI: 10.1038/ s41419 -020- 2570-5
12. Zhao K^#, Cheng S^#, Miao N^#, Xu P^#, Lu X^#, Zhang Y^#, Wang M, Ouyang X, Yuan X, Liu W, Lu X, Zhou P, Gu J, Zhang Y, Qiu D, Jin Z, Su C, Peng C, Wang JH, Dong MQ, Wan Y, Ma J, Cheng H, Huang Y*, Yu Y*.A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation. ?Nature Cell Biology (2019) 21(10):1261-1272.
13. Shin J, Cheng H*, Tian B*. New means to an end: mRNA export activity impacts alternative polyadenylation. Transcription (2019) DOI: 10.1080/21541264.2019.1658557
14. Chen SL^#, Wang RJ^#, Zheng DH^#, Zhang H^#, Chang XY, Wang K, Li WC, Fan J, Tian B*, Cheng H*. The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation, and mRNA export. Mol Cell (2019) 74(1):118-131
15. Wang JS^#, Chen JY^#, Wu GF^#, Zhang HL^#, Du X^#, Chen SL, Zhang L, Wang K, Fan J, Gao SX, Wu XD, Zhang SX, Kuai B, Zhao P, Chi BK, Wang LT, Li GH, Wong CCL, Zhou Y*, Li JS*, Yun CH*, Cheng H*. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev (2019) 33(9-10):536-549
16. Wang K, Yin CP, Du X, Chen SL, Wang JS, Zhang L, Wang LT, Yu Y, Chi BK, Shi M, Wang CS, Reed R, Zhou Y, Huang J, Cheng H*. A U2 snRNP independent role of SF3b in promoting mRNA export. Proc Natl Acad Sci USA (2019) 116(16):7837-7846
17. Fan J, Wang K, Du? X, Wang JS, Chen SL, Wang YM, Shi M, Zhang L, Wu XD, Zheng DH, Wang CS, Wang LT, Tian B, Li GH, Zhou Y, Cheng H*. ALYREF links 3’-end processing to nuclear export of non-polyadenylated mRNAs. EMBO J (2019) 38(9)DOI: 10.15252/embj.201899910
18. Wang K, Wang LT, Wang JS, Chen SL, Shi M, Cheng H*. Intronless mRNAs transit through nuclear speckles to gain export competence. J?Cell?Biol (2018) 217: 3912-3929. (Recommended by F1000Prime)
19. Fan J^#, Kuai B^#,?Wang K^#, Wang LT,?Wang YM, Wu XD, Chi BK, Li GH, Cheng H*. mRNAs are sorted for export or degradation before passing through nuclear speckles. Nucleic Acids Res (2018) 46: 8404-8416
20. Lan PF^#, Tan M^#, Zhang YB^#, Niu SS, Chen J, Shi SH, Qiu SW, Wang XJ, Peng XD, Cai G, Cheng H, Wu J*, Li GH*, Lei M*. Structural insight into precursor tRNA processing by yeast ribonuclease P. Science (2018) 362(6415). DOI:10.1126/science.aat6678
21. Wang K, Shi M, Cheng H*. Microinjection and fluorescence in situ hybridization assay for studying mRNA export in mammalian cells. Methods Mol Biol(2017) 1648:95-102
22. Shi M, Zhang H, Wu XD, He ZS, Wang LT, Yin SY, Tian B, Li GH*, Cheng H*. ALYREF mainly binds to the 5’ and the 3’ regions of the mRNA in vivo. Nucleic Acids Res (2017) 45: 9640-9653
23. Fan J^#, Kuai B^#, Wu GF, Wu XD, Chi BK, Wang LT, Wang K, Shi ZB, Zhang H, Chen S, He ZS, Wang SY, Zhou ZC, Li GH*, Cheng H*.Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export. EMBO J (2017) 36: 2870-2886
24. Zhang DL, Chen DF, Cao LR, Li GH*, Cheng H*. The effect of codon mismatch on the protein translation system. PLoS One (2016) 11(2):e0148302. DOI:10.1371/journal.pone.0148302
25. Shi M^#, Zhang H^#, Wang LT^#, Zhu CL, Sheng K, Du YH, Wang K, Dias A, Chen S, Whitman M, Wang ED, Reed R *, Cheng H*. Premature termination codons are recognized in the nucleus in a reading-frame dependent manner. Cell Discov (2015) 1, 15001. DOI: 10.1038/celldisc.2015.1
26. Chi BK, Wang K, Du YH, Gui B, Chang XY, Wang LT, Fan J, Chen S, Wu XD, Li GH*, Cheng H*. A sub-element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18.Nucleic Acids Res (2014) 42: 7305-18
27. Chi BK^#, Wang QL^#, Wu GF, Tan M, Wang LT, Shi M, Chang XY, Li GH, Cheng H*. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Nucleic Acids Res (2013) 41: 1294-1306
28. Liu HJ^#, Wu ZT^#, Shi XL^#, Li WZ^#, Liu C, Wang DK, Ye XY, Liu L, Na J*, Cheng H*, Chen LY*. Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction. Dev Biol (2013) 375: 13-22
29. Wu ZT, Yang M, Liu HJ, Guo HC, Wang Y, Cheng H, Chen LY*. Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem (2012) 287: 38295-304
30. Cheng H, Dufu K, Valencia P, Reed R*. mRNA Export. Encyclopedia of Life Sciences (eLS) (2007) DOI: 10.1002/9780470015902.a0005977.pub2
31. Cheng H, Dufu K, Lee CS, Hsu J. Dias A, Reed R*. Human mRNA export machinery recruited to the 5′ end of mRNA. Cell (2006) 127: 1389-400
32. Reed R*, Cheng H. TREX, SR proteins and export of mRNA. Curr Opin Cell Biol (2005) 17: 269-73
33. Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R*. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev (2005) 19: 1512-7
34. Cheng H^#, Sugiura R^#, Wu WL, Fujita M, Lu YB, Sio SO, Kawai R, Takegawa K, Shuntoh H, Kuno T*. Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function. Mol Biol Cell (2002) 13: 2963-76
35. Lu YB, Sugiura R, Yada T, Cheng H, Sio SO, Shuntoh H, Kuno T*. Calcineurin is implicated in the regulation of the septation initiation network in fission yeast. Cover story. Genes to Cells (2002) 7: 1009-19

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